Synthesis of two dopamine D4 receptor ligands: 11C labelled chromeno [3, 4??c] pyridin??5??ones

…, G Slegers, RA Dierckx, J De Reuck

文献索引：Vos, F. De; Dumont, F.; Santens, P.; Slegers, G.; Dierckx, R. A.; Reuck, J. De Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 10 p. 989 - 996

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被引用次数: 10

摘要

Abstract The synthesis of two 11 C labelled chromeno [3, 4-c] pyridin-5-ones for the visualisation of the dopamine D4 receptor subtype has been developed. The production entailed an O-methylation of the O-desmethyl precursor with [11 C] iodomethane in the presence of tetrabutylammonium hydroxide. Subsequent purification by RP-HPLC and formulation by tracer enrichment on a C18 Sep Pak provided a solution which was ...