A novel series of 2, 6, 7-substituted 2, 3-dihydro-1, 4-benzodioxin and 2, 6, 7-substituted 1, 4-benzodioxin derivatives as lipid peroxidation inhibitors. Structure-activity …
A series of 6-or 7-substituted 2-carboxamido-or 2-(aminomethyl)-1, 4-benzodioxin and-2, 3- dihydro-1, 4-benzodioxin derivatives were synthesized and evaluated to determine the necessary structural requirements for a high inhibition of human low-density lipoprotein copper-induced peroxidation. The most active compounds (21, 25, 28, 36, and 37) were found between 5 and> 45 times more active than probucol itself. Due to both their potency ...
