Rationally Designed Inhibitors of Inosine Monophosphate Dehydrogenase∇

…, K Rao, SF Carr, E Papp, K Straub, JC Wu…

文献索引：Zhang, Han-Zhong; Rao, Kotesvar; Carr, Stephen F.; Papp, Eva; Straub, Kenneth; Wu, John C.; Fried, Josef Journal of Medicinal Chemistry, 1997 , vol. 40, # 1 p. 4 - 8

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被引用次数: 24

摘要

Functionalized 2-alkyl derivatives of inosinic acid have been synthesized to serve as reversible as well as irreversible inhibitors of the human type II enzyme inosine monophosphate dehydrogenase. These compounds were designed to react with Cys-331 of the enzyme to form covalent bonds so as to interfere with the normal enzyme mechanism which involves attack of Cys-331 at C-2 of the substrate. Mass spectrometric analysis of ...