Synthesis and leishmanicidal activity of cinnamic acid esters: Structure–activity relationship

…, SM Robledo, S Díaz, M Carda, D Muñoz…

文献索引：Otero, Elver; Robledo, Sara M.; Diaz, Santiago; Carda, Miguel; Munoz, Diana; Panos, Julian; Velez, Ivan D.; Cardona, Wilson Medicinal Chemistry Research, 2014 , vol. 23, # 3 p. 1378 - 1386

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被引用次数: 6

摘要

Abstract Several cinnamic acid esters were obtained via Fischer esterification of cinnamic acids derivatives with aliphatic alcohols. Structures of the products were elucidated by spectroscopic analysis. The synthesized compounds were evaluated for antileishmanial activity against L.(V) panamensis amastigotes and cytotoxic activity was evaluated against mammalian U-937 cells. The compounds 11, 15–17, and 23, were active against ...