Chlorzoxazone esters of some non-steroidal anti-inflammatory (NSAI) carboxylic acids as mutual prodrugs: Design, synthesis, pharmacological investigations and …
…, AA Abdel-Hafez, GS El-Karamany, HH Farag
文献索引：Abdel-Azeem, Ahmed Z.; Abdel-Hafez, Atef A.; El-Karamany, Gamal S.; Farag, Hassan H. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 10 p. 3665 - 3670
The discovery of the inducible isoform of cyclooxygenase enzyme (COX-2) spurred the search for anti-inflammatory agents devoid of the undesirable effects associated with classical NSAIDs. New chlorzoxazone ester prodrugs (6–8) of some acidic NSAIDs (1–3) were designed, synthesized and evaluated as mutual prodrugs with the aim of improving the therapeutic potency and retard the adverse effects of gastrointestinal origin. The structure ...
