Tetrahedron letters

(R, S) 2-fluoro (chloro)-4′-carboxy-triphenyl methanol. Novel acid labile trityl type handles for solid phase peptide synthesis

CC Zikos, NG Ferderigos

文献索引：Zikos, Christos C.; Ferderigos, Nicolas G. Tetrahedron Letters, 1994 , vol. 35, # 11 p. 1767 - 1768

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被引用次数: 32

摘要

Abstract Novel trityl type handles have been prepared and applied to solid phase synthesis using 9-fluorenylmethyloxycarbonyl (Fmoc) for N a-amino protection and acid labile protecting groups for side chain protection. The cleavage of the resultant ester can be carried out by using appropriate mild acidic cocktails 0.1%(v/v) trifluoroacetic acid, and TFE: CH 2 Cl 2: CH 3 COOH 1: 8: 1 (v/v).