Synthesis and biological evaluation of RGD peptides with the 99m Tc/188 Re chelated iminodiacetate core: highly enhanced uptake and excretion kinetics of …
…, JS Kim, JH Jung, HS Park, JA Katzenellenbogen…
文献索引：Lee, Byung Chul; Moon, Byung Seok; Kim, Ji Sun; Jung, Jae Ho; Park, Hyun Soo; Katzenellenbogen, John A.; Kim, Sang Eun RSC Advances, 2013 , vol. 3, # 3 p. 782 - 792
To develop a companion set of RGD-based agents for diagnostic and radiotherapeutic purposes, facile incorporation of 99mTc (CO) 3 or 188Re (CO) 3 into the same precursor produced, respectively, a structurally and functionally matched radiodiagnostic and radiotherapeutic—or theranostic—pair. This work presents the synthesis of two 99mTc- labeled RGD monomers (4 and 5) along with a 99mTc-labeled RGD dimer (6) and an ...
