Synthesis and Evaluation of a Series of 3, 4, 5??Trimethoxycinnamic Acid Derivatives as Potential Antinarcotic Agents

JC Jung, S Moon, D Min, WK Park…

文献索引：Jung, Jae-Chul; Moon, Sohyeon; Min, Dongguk; Park, Woo Kyu; Jung, Mankil; Oh, Seikwan Chemical Biology and Drug Design, 2013 , vol. 81, # 3 p. 389 - 398

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被引用次数: 2

摘要

A series of 3, 4, 5-trimethoxycinnamic acid derivatives was prepared and evaluated for antinarcotic effects on morphine dependence in mice and binding affinities on serotonergic receptors. The key synthetic strategies involve generation of ketones 6–7, esters 9–12 through condensation reaction, and amides 13–19 via coupling reaction using 1- hydroxybenzotriazole⁄ ethyl (dimethylaminopropryl) carbodiimide system in high yield. We ...