Regioselective metalation of fluoroanilines. An application to the synthesis of fluorinated oxazolidinone antibacterial agents

…, MR Barbachyn, SJ Brickner, SA Mizsak

文献索引：Grega, Kevin C.; Barbachyn, Michael R.; Brickner, Steven J.; Mizsak, Stephen A. Journal of Organic Chemistry, 1995 , vol. 60, # 16 p. 5255 - 5261

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被引用次数: 55

摘要

The oxazolidinones, exemplified by DuP 721 (l), are a relatively new class of orally active, totally synthetic antibacterial agents. 2 Their spectrum of activity encompasses Gram- positive aerobic bacteria, including methicillin-resistant Staphylococcw aureus (MRSA), and anaer-obic organism^.^ Preliminary inquiries into the mechanism of action of the oxazolidinones revealed that they are bacterial protein synthesis inhibitors, with inhibition ...