Synthesis of optically pure (R)-and (S)-α-trifluoromethyl-alanine

P Bravo, S Capelli, SV Meille, F Viani, M Zanda…

文献索引：Bravo, Pierfrancesco; Capelli, Silvia; Meille, Stefano Valdo; Viani, Fiorenza; Zanda, Matteo; et al. Tetrahedron: Asymmetry, 1994 , vol. 5, # 10 p. 2009 - 2018

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被引用次数: 68

摘要

Abstract (+)-(R)-and (−)-(S)-3, 3, 3-trifluoro-2-methyl-alanine (1) were synthesized from (+)- (R)-methyl-p-tolyl-sulphoxide (5) and N-alkoxycarbonylimino derivatives 4 of methyl 3, 3, 3- trifluoropyruvate (3). The absolute configuration was determined by X-ray analyses of two synthetic intermediates (2S, RS)-6a and (2R, R S-6c.