Highly Regio??and Stereoselective Synthesis of Multialkylated Olefins through Carbozirconation of Alkynylboronates and Sequential Negishi and Suzuki–Miyaura …
The regio-and stereoselective synthesis of multisubstituted olefins is one of the most challenging tasks in synthetic organic chemistry.[1] Established synthetic methods to directly construct carbon–carbon double bonds, such as Wittig, Horner–Wadsworth–Emmons, or olefin metathesis have limitations and often afford inseparable mixtures of stereoisomers. Recent advances in carbometalation or bimetalation/cross-coupling strategies have ...
