Chemistry of Heterocyclic Compounds

Antitumor antibiotics: duocarmycins

S Nagamura, H Saito

文献索引：Nagamura, Satoru; Saito, Hiromitsu Chemistry of Heterocyclic Compounds, 1998 , vol. 34, # 12 p. 1386 - 1405

全文：HTML全文

被引用次数: 7

摘要

In our continuing search for biologically active compounds from microorganisms to develop new alkylating agents and other compounds that interfere with the functioning of DNA, novel potent antitumor antibiotics designated duocarmycins were isolated from three different Streptomyces species. The producing organisms of duocarmycin A (1) [1-5], that of duocarmycin B1 (2) [6], B2 (3) [7], C1 (4) [8], and C2 (5) [9, 10], and that of duocarmycin SA (6) [11, 12] were ...