Synthesis of water soluble 8??substituted 5??deazaflavins

P Link, HC Van Der Plas…

文献索引：Link, P. A. J.; Plas, H. C. van der; Mueller, F. Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 873 - 878

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被引用次数: 10

摘要

Abstract By oxidative cyclization of 5, 5′-arylmethylenebis (6-methylaminouracil) derivatives with diethyl azodicarb-oxylate a number of 5-deazaisoalloxazines were synthesized having at the C (8) position a substituent that causes a bathochromic shift varying between 20 and 130 nm, depending on the substituent. To increase the solubility in aqueous media 8-substituted 5-deazaflavins were prepared having a carboxymethyl ...