Identification of a series of 1, 2, 3, 4-tetrahydroisoquinolinyl-benzamides with potential anticonvulsant activity

…, MS Hadley, JD Harling, HJ Herdon, JC Jerman…

文献索引：Chan, Wai N.; Hadley, Michael S.; Harling, John D.; Herdon, Hugh J.; Jerman, Jeffrey C.; Orlek, Barry S.; Stean, Tania O.; Thompson, Mervyn; Upton, Neil; Ward, Robert W. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 20 p. 2903 - 2906

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被引用次数: 7

摘要

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of N-(tetrahydroisoquinolinyl)-2-methoxybenzamides was identified by high-throughput screening at the novel SB-204269 binding site. SAR studies have provided compounds 4 and 14 with high affinity and good anticonvulsant activity in animal models.