N-Benzylindole-2-carboxylic acids: potent functional antagonists of the CCR2b chemokine receptor

JG Kettle, AW Faull, AJ Barker, DH Davies…

文献索引：Kettle, Jason G.; Faull, Alan W.; Barker, Andy J.; Davies, D. Huw; Stone, Michael A. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 2 p. 405 - 408

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被引用次数: 29

摘要

Screening of the corporate database led to the discovery of a novel series of N-benzylindole- 2-carboxylic acid CCR2b chemokine receptor antagonists. These compounds demonstrate high affinity and functional inhibition of the CCR2b receptor. A discussion of the structure– activity relationships is presented, together with evidence for a highly selective receptor binding profile.