Tetrahedron

Molecular design of glutathione-derived biochemical probes targeting the GS-X pump

K Furuta, K Tomokiyo, MT Kuo, T Ishikawa, M Suzuki

文献索引：Furuta, Kyoji; Tomokiyo, Keiichiro; Tien Kuo; Ishikawa, Toshihisa; Suzuki, Masaaki Tetrahedron, 1999 , vol. 55, # 24 p. 7529 - 7540

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被引用次数: 16

摘要

The syntheses of novel glutathione derivatives as photoaffinity and fluorescent biochemical probes for the GS-X pump are described. GIF-0017, an S-alkylated glutathione derivative with a benzophenone photophore, competitively inhibits the transport of leukotriene C4 by the GS-X pump with an IC50 value of 0.40 μM, indicating the existence of strong interaction between the probe molecule and the GS-X pump.