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Design, synthesis, biological evaluation and docking studies of pterostilbene analogs inside PPARα

…, G Ma, S Khan, A Patny, MA Avery, AM Rimando

文献索引:Mizuno, Cassia S.; Ma, Guoyi; Khan, Shabana; Patny, Akshay; Avery, Mitchell A.; Rimando, Agnes M. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 7 p. 3800 - 3808

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被引用次数: 52

摘要

Pterostilbene, a naturally occurring analog of resveratrol, has previously shown PPARα activation in H4IIEC3 cells and was found to decrease cholesterol levels in animals. In this study, analogs of pterostilbene were synthesized and their ability to activate PPARα was investigated. Among analogs that was synthesized (E)-4-(3, 5-dimethoxystyryl) phenyl dihydrogen phosphate showed activity higher than pterostilbene and control drug ...