Discovery of 5-chloro-N 2-[(1 S)-1-(5-fluoropyrimidin-2-yl) ethyl]-N 4-(5-methyl-1 H-pyrazol-3-yl) pyrimidine-2, 4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat …

S Ioannidis, ML Lamb, T Wang, L Almeida…

文献索引：Journal of Medicinal Chemistry, , vol. 54, # 1 p. 262 - 276

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被引用次数: 85

摘要

... Journal of Medicinal Chemistry. ... or more myeloid lineages. Among these, MF represents the greatest unmet medical need and has been the starting point for clinical trials of Jak2 inhibitors. Typical clinical features of ...