Tetrahedron

Versatile strategies for the solid phase synthesis of small heterocyclic scaffolds:[1, 3, 4]-thiadiazoles and [1, 3, 4]-oxadiazoles

R Severinsen, JP Kilburn, JF Lau

文献索引：Severinsen, Rune; Kilburn, John Paul; Lau, Jesper F. Tetrahedron, 2005 , vol. 61, # 23 p. 5565 - 5575

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被引用次数: 54

摘要

New robust protocols for the solid phase synthesis of 5-alkylthio-, 5-alkyl/aryl-, and 5- acylamino-2-alkylamino-[1, 3, 4]-thiadiazoles are described based on a common resin bound thiosemicarbazide. A protocol for the solid phase synthesis of 2-alkyl/aryl-amino-5- alkylamino-[1, 3, 4]-oxadiazoles from a resin bound semicarbazide is likewise reported. The protocols have been verified by the preparation of four small libraries that all gave ...