Tetrahedron

Palladium catalyzed tandem alkenyl-and aryl-C–N bond formation: a cascade N-annulation route to 4-, 5-, 6-and 7-chloroindoles

LC Henderson, MJ Lindon, MC Willis

文献索引：Henderson, Luke C.; Lindon, Matthew J.; Willis, Michael C. Tetrahedron, 2010 , vol. 66, # 33 p. 6632 - 6638

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被引用次数: 20

摘要

A series of trihalogenated alkenylbenzenes undergo consecutive palladium catalyzed inter- and intramolecular amination reactions to deliver a series of 1-functionalized mono- chloroindoles. 4-, 5-, 6-and 7-Chloroindoles can all be prepared; carbamates, anilines and amines can be employed as the N-nucleophile.