Discovery of a novel class of orally active, non-peptide angiotensin II antagonists

B De, M Winn, TM Zydowsky, DJ Kerkman…

文献索引：De, B.; Winn, M.; Zydowsky, T. M.; Kerkman, D. J.; DeBernardis, J. F.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 20 p. 3714 - 3717

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被引用次数: 44

摘要

The renin-angiotensin system (RAS) plays a pivotal role in the regulation of blood pressure, volume homeostasis, and salt retention. Angiotensin 11, an octapeptide produced by the action of angiotensin converting enzyme (ACE) on angiotensin I, is the most potent pressor agent and the penultimate product of this cascade (Scheme I). In addition to its hypertensive effects, angiotensin I1 also has mitogenic effects on vascular tissue and stimulates renal ...