Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating …
…, JL Montero, A Scozzafava, D Vullo…
文献索引：Winum, Jean-Yves; Vullo, Daniela; Casini, Angela; Montero, Jean-Louis; Scozzafava, Andrea; Supuran, Claudiu T. Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5471 - 5477
Targeting proteins overexpressed in hypoxic tumors is as an important means of controlling cancer disease. One such protein is the carbonic anhydrase (CA) isoenzyme IX, which in some types of tumors is overexpressed 150-200-fold. We report here a series of sulfonamide derivatives, prepared from 2-carbohydrazido-and 4-carbohydrazido-benzenesulfonamides, which were further derivatized by reaction with aryl isocyanates or arylsulfonyl ...
