Synthesis and antifertility activity of 5-(phenoxymethyl)-2-oxazolidinethiones

GA Youngdale, GW Duncan, DE Emmert…

文献索引：Youngdale; Duncan; Emmert; Lednicer Journal of medicinal chemistry, 1966 , vol. 9, # 1 p. 155 - 157

被引用次数: 20

摘要

As part of a program toward the preparation of potential muscle relaxants, 5-(aa, a-trifluoro- m-tolyloxymethyl)-2-oxazolidinethione (38) was synthesized. Though the compound was found to have only minimal activity on the loss of righting reflex,'additional testing uncovered the fact that it\\ ai active a $ an antifertility agent? in the female rat. I11 ail effort to deteriiiiiie the structural features required for activity, a number of aiialog? were prepared. The,~-l) ...