Design, synthesis and antibacterial activity of novel N-formylhydroxylamine derivatives as PDF inhibitors

L Yin, J Jia, GL Zhao, WR Xu, LD Tang…

文献索引：Yin; Jia; Zhao; Xu; Tang; Wang Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2011 , vol. 50, # 5 p. 695 - 703

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被引用次数: 5

摘要

Abstract: A new series of N-formylhydroxylamines 11a-i have been synthesized through a multi-step protocol starting from diethyl malonate. These compounds have been structurally characterized by IR, 1 H NMR and HRMS. All the synthesized compounds 11a-i have been screened for antibacterial activities. All the compounds are found to exhibit potent in vitro inhibitory activity against Staphylococcus aureus and relatively weak antibacterial activity ...