Journal of the American Chemical Society

2-Aroylbenzoyl serine proteases: photoreversible inhibition or photoaffinity labeling?

PB Jones, NA Porter

文献索引：Jones, Paul B.; Porter, Ned A. Journal of the American Chemical Society, 1999 , vol. 121, # 12 p. 2753 - 2761

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被引用次数: 21

摘要

Phenyl esters of 2-benzoylbenzoates were determined to be inhibitors of the serine protease enzymes chymotrypsin and thrombin. Thus, p-guanidinophenyl 2-benzoylbenzoate (1b) inhibited thrombin while the corresponding p-nitrophenyl ester (1a) inhibited chymotrypsin activity. Other p-nitrophenyl esters were prepared that display activity as chymotrypsin inhibitors, three having methoxy group substitution on the benzoyl ring: 2-methoxy (2a), 2, ...