Synthetic Communications®

Novel Synthesis of Differentially Substituted 5, 7-Dialkoxyquinazolin-4-ones

KM Foote, G Hatter

文献索引：Foote, Kevin M.; Hatter, Glenn Synthetic Communications, 2008 , vol. 38, # 15 p. 2575 - 2583

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摘要

As part of our more recent work on inhibitors of the EGFR [ 3 3. Ballard , P. ; Bradbury , RH ; Harris , CS ; Hennequin , LFA ; Hickinson , M. ; Johnson , PD ; Kettle , JG ; Klinowska , T. ; Leach , AG ; Morgentin , R. ; Pass , M. ; Ogilvie , DJ ; Olivier , A. ; Warin , N. ; Williams , EJ Inhibitors of epidermal growth factor receptor tyrosine kinase: Novel C-5 substituted anilinoquinazolines designed to target the ribose pocket . Bioorg. & Med. Chem. Letters 2006 , 16 , 1633 – 1637 .