New routes to 5-substituted oxazoles

MS Addie, RJK Taylor

文献索引：Addie, Matthew S.; Taylor, Richard J.K. Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 4 p. 527 - 531

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被引用次数: 17

摘要

The hazards associated with this alkyl isocyanide can be largely avoided by employing tosylmethyl isocyanide (TosMIC). The reaction of TosMIC with aldehydes under basic conditions affords 5-substituted oxazoles directly, as described by van Leusen et al., 8 although this method is limited by the availability and/or stability of the requisite aldehyde. The reaction of the TosMIC anion with carboxylic acid chlorides 8 , anhydrides 8 and esters 9 has also been carried out by ...