Abstract Friedel–Crafts acylation of highly activated aromatic nuclei is rendered difficult by the fact that extensive complexation of the substrate by the Lewis acid catalyst inevitably takes place, which deactivates more or less completely such reagents. 2 (3 H)?? benzoxazolones and their sulfur bioisosters were chosen as model molecules in an effort to search for an efficient alternative method to the Friedel–Crafts reaction. 6?? ...
