Tetrahedron

A one-pot three-component reaction for the preparation of highly functionalized tryptamines

SJ Yeo, Y Liu, X Wang

文献索引：Yeo, Se Jeong; Liu, Yongxiang; Wang, Xiang Tetrahedron, 2012 , vol. 68, # 3 p. 813 - 818

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被引用次数: 14

摘要

We have developed a general one-pot method to provide highly functionalized tryptamine derivatives, via a Fischer indole type pathway. In this article, we demonstrate optimal conditions for a one-pot indole synthesis, allowing for the synthesis of a broad scope of 2- methyl tryptamine derivatives and a precursor for the synthesis of the core structure of some akuammiline alkaloids. Additionally, further modification of the indole products is ...