Abstract The preparation of 4-and 5-acyl-and aroyl-2-substituted aminothiazoles is described. The condensation of thioureas with acyl halides leading to 4, 5-disubstituted-2- aminothiazoles and 7-(4H) benzothiazolones is discussed. A discussion of the isolation of various intermediates and the mechanistic pathway is also included. A number of 2-anilino or 2-benzyl-4-or 5-aroylthiazoles possessed moderate oral antitubercolosis activity (2).
