Truncated phosphonated C-1′-branched N, O-nucleosides have been synthesized in good yields by 1, 3-dipolar cycloaddition methodology, starting from N-methyl-C- (diethoxyphosphoryl) nitrone 7. Preliminary biological assays show that β-anomers are able to inhibit HIV in vitro infection at concentrations in the micromolar range. Higher SI values with respect to AZT indicated that the compounds were endowed with low cytotoxicity.
