Organic letters

Preparation of bicyclic 1, 2, 4-trioxanes from γ, δ-unsaturated ketones

AP Ramirez, AM Thomas, KA Woerpel

文献索引：Ramirez, Armando P.; Thomas, Andrew M.; Woerpel Organic Letters, 2009 , vol. 11, # 3 p. 507 - 510

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被引用次数: 19

摘要

Treatment of γ, δ-unsaturated ketones with hydrogen peroxide and acid provides a rapid entry into the medicinally important 1, 2, 4-trioxane structure. Alkene substitution that stabilizes carbocationic intermediates proved to be important for the success of this transformation.