Bis (1H-pyrazol-1-yl)-and bis (1H-imidazol-1-yl) pyrimidines were synthesized and evaluated for cytoprotective effects. Among them, 4, 6-bis (1H-pyrazol-1-yl) pyrimidine (3) showed a potent inhibitory effect on the HCl· ethanol-, ethanol-, and water immersion stress- induced gastric lesions in rats, and a very low acute toxicity. One of the major factors reponsible for the cytoprotective effects of 3 is the increase in the bicarbonate secretion. ...
