Catalysis of the β-elimination of HF from isomeric 2-fluoroethylpyridines and 1-methyl-2-fluoroethylpyridinium salts. Proton-activating factors and methyl-activating …

…, V Laureti, L Ottavi, R Ruzziconi

文献索引：Alunni, Sergio; Laureti, Valeria; Ottavi, Laura; Ruzziconi, Renzo Journal of Organic Chemistry, 2003 , vol. 68, # 3 p. 718 - 725

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被引用次数: 25

摘要

Second-order rate constants, k OHN, M-1 s-1, for the β-elimination reactions of HF with 2-(2- fluoroethyl) pyridine (2), 3-(2-fluoroethyl) pyridine (3), and 4-(2-fluoroethyl) pyridine (4) in OH- /H2O, at 50° C and μ= 1 M KCl, are= 0.646× 10-4 M-1 s-1,= 2.97× 10-6 M-1 s-1, and= 5.28× 10-4 M-1 s-1, respectively. When compared with the second-order rate constants for the same processes with the nitrogen-methylated substrates 1-methyl-2-(2-fluoroethyl) ...