Tetrahedron: Asymmetry

Resolution of enantiomers of [α-hydroxy-(o-chlorophenyl) methyl] phosphinic acid via diastereomeric salt formation with enantiopure 1-phenylethylamines

B Kaboudin, S Alaie, T Yokomatsu

文献索引：Kaboudin, Babak; Alaie, Saied; Yokomatsu, Tsutomu Tetrahedron Asymmetry, 2011 , vol. 22, # 18-19 p. 1813 - 1816

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被引用次数: 10

摘要

The resolution of racemic α-hydroxy-H-phosphinic acid with enantiopure 1- phenylethylamines via diastereomeric salt formation was investigated. X-Ray crystallographic analysis of the salt revealed that (R)-1-phenylethylamine to be efficient resolving agent for obtaining a single enantiomer of [α-hydroxy-(o-chlorophenyl) methyl] phosphinic acid. Resolving racemic α-hydroxy-H-phosphinic acid with (S)-2- ...