Synthesis and antitumor activity of 1, 3, 4-oxadiazole possessing 1, 4-benzodioxan moiety as a novel class of potent methionine aminopeptidase type II inhibitors
A series of 1, 3, 4-oxadiazole derivatives containing 1, 4-benzodioxan moiety (7a–7q) have been designed, synthesized and evaluated for their antitumor activity. Most of the synthesized compounds were proved to have potent antitumor activity and low toxicity. Among them, compound 7a showed the most potent biological activity against Human Umbilical Vein Endothelial cells, which was comparable to the positive control. The results ...
