FK463, a Novel Water-soluble Echinocandin Lipopeptide. Synthesis and Antifungal Activity.

M Tomishima, H Ohki, A Yamada, H TAKASUGI…

文献索引：Tomishima; Ohki; Yamada; Takasugi; Maki; Tawara; Tanaka Journal of Antibiotics, 1999 , vol. 52, # 7 p. 674 - 676

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被引用次数: 122

摘要

Anincreasing numberof patients with markedimmuno-suppression as a result of transplantation, cancer and infection with Hiy has led to the increased, and widespread use of systemic antifungal agents. 1} Currently available treatment is limited to 5-fluorocytosine, amphotericin B and azoles such as fluconazole and itraconazole. However, various problems effect the use of these agents. Among the major concerns are toxicity, rapid ...