Discovery of α-amidosulfones as potent and selective agonists of CB 2: Synthesis, SAR, and pharmacokinetic properties

…, EF DiMauro, A Cheng, R Emkey, SA Hitchcock…

文献索引：Marx, Isaac E.; DiMauro, Erin F.; Cheng, Alan; Emkey, Renee; Hitchcock, Stephen A.; Huang, Liyue; Huang, Ming Y.; Human, Jason; Lee, Josie H.; Li, Xingwen; Martin, Matthew W.; White, Ryan D.; Fremeau Jr., Robert T.; Patel, Vinod F. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 1 p. 31 - 35

全文：HTML全文

被引用次数: 26

摘要

A series of α-amidosulfones were found to be potent and selective agonists of CB2. The discovery, synthesis, and structure–activity relationships of this series of agonists are reported. In addition, the pharmacokinetic properties of the most promising compounds are profiled.