Tetrahedron letters

(E)-Selective Horner–Wadsworth–Emmons reaction of aryl alkyl ketones with bis (2, 2, 2-trifluoroethyl) phosphonoacetic acid

S Sano, Y Takemoto, Y Nagao

文献索引：Sano, Shigeki; Takemoto, Yuka; Nagao, Yoshimitsu Tetrahedron Letters, 2003 , vol. 44, # 49 p. 8853 - 8855

全文：HTML全文

被引用次数: 13

摘要

Recently, a number of studies have attempted to develop a highly stereoselective method for synthesizing trisubstituted alkenes. 1., 2., 3. and 4. Although one such method, the stereoselective Horner–Wadsworth–Emmons (HWE) reaction of aldehydes, has been well established, 5., 6. and 7. moderate reactivity and selectivity are generally observed in the HWE reactions with ketones. 8. and 9. We have previously reported a versatile method for the stereoselective ...