Design, synthesis and biological evaluation of novel, simplified analogues of laulimalide: modification of the side chain

…, A Longstaff, D Wong, I Barasoain, RM Buey…

文献索引：Paterson, Ian; Menche, Dirk; Hakansson, Anders E.; Longstaff, Adrian; Wong, David; Barasoain, Isabel; Buey, Ruben M.; Diaz, J. Fernando Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 9 p. 2243 - 2247

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被引用次数: 36

摘要

Novel, simplified analogues of the microtubule-stabilizing anticancer agent laulimalide, including the first derivatives with unnatural side chains, were designed by molecular modelling, synthesized by a late-stage diversification strategy, and evaluated in vitro for growth inhibition of human ovarian carcinoma cell lines (A2780, A2780/AD10).