Analogues of 4, 5-bis (3, 5-dichlorophenyl)-2-trifluoromethyl-1H-imidazole as potential antibacterial agents

M Antolini, A Bozzoli, C Ghiron, G Kennedy…

文献索引：Antolini, Marinella; Bozzoli, Andrea; Ghiron, Chiara; Kennedy, Gordon; Rossi, Tino; Ursini, Antonella Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 7 p. 1023 - 1028

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被引用次数: 148

摘要

A preliminary exploration of analogues of 4, 5-bis (3, 5-dichlorophenyl)-2-trifluoromethyl-1H- imidazole, 1, as novel antibacterial agents was carried out to determine the basic features of the structure responsible for the observed biological activity. The presence of two aryl rings, the imidazole NH and either a good electron withdrawing group or an aldehyde or amino group at C-2 were required for good levels of activity against methicillin resistant ...