Optimisation of ITK inhibitors through successive iterative design cycles

M Herdemann, A Weber, J Jonveaux…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 6 p. 1852 - 1856

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被引用次数: 14

摘要

... Bioorganic & Medicinal Chemistry Letters. ... Prior to synthesis, chemical accessible modifications at position 6 of the indole motif as well as at position 5 of the pyrazolopyridine moiety of 4a were virtually enumerated and docked in the ATP binding pocket of ITK. ...