Substituted oxirane-2-carboxylates such as palmoxirate, 1 clomoxir, 2 etomoxir, 3 JG381 4 have been recognized as powerful hypoglycemic agents in animals including humans. Their hypoglycemic effect was associated with the irreversible inhibition of carnitine palmitoyl transferase I (CPT I), which is essential for the transportation of palmitoyl CoA into the mitochondria matrix side for its β-oxidation 5 . ... The further mechanistic investigation revealed that only the (R)- ...
