Tetrahedron Letters

Synthetic study on breynin A: Synthesis of breynolide sulfone

S Nishiyama, Y Ikeda, S Yoshida, S Yamamura

文献索引：Nishiyama; Ikeda; Yoshida; Yamamura Tetrahedron Letters, 1989 , vol. 30, # 1 p. 105 - 108

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被引用次数: 25

摘要

Abstract In connection with breynin A having a significant hypocholesterolemic activity in rats, an optically active perhydrobenzothiophene has been synthesized starting from L- carvone in 11% overall yield. Furthermore, this sulfur-containing bicyclic segment has been successfully converted into an oxygenated breynolide.