Mechanism for the stabilization in vivo of the aziridine precursor 2-(4-acetoxyphenyl)-2-chloro-N-methyl-ethylammonium chloride by serum proteins

…, P Swart, SS de Kock, KJ van der Merwe

文献索引：Louw, Ann; Swart, Pieter; De Kock, Schalk S.; Van Der Merwe, Kirsten J. Biochemical Pharmacology, 1997 , vol. 53, # 2 p. 189 - 197

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被引用次数: 48

摘要

Oral and intraperitoneal administration of 2-(4-acetoxyphenyl)-2-chloro-N-methyl- ethylammonium chloride (Compound A), an analogue of phenyl aziridine precursors that occur in the shrub Salsola tuberculatiformis Botsch., had a contraceptive effect on female Wistar rats with a concomitant decrease in total body, uterus, and ovary mass and an increase in adrenal mass. Compound A elicited a Type II difference spectrum and ...