Discovery of novel 2, 8-diazaspiro [4.5] decanes as orally active glycoprotein IIb-IIIa antagonists

MM Mehrotra, JA Heath, MS Smyth…

文献索引：Journal of Medicinal Chemistry, , vol. 47, # 8 p. 2037 - 2061

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被引用次数: 21

摘要

... Journal of Medicinal Chemistry. ... Abstract. Abstract Image. In our efforts to develop orally active GPIIb-IIIa antagonists with improved pharmaceutical properties, we have utilized a novel 2,8-diazaspiro[4.5]decane scaffold as a template. ...