Abstract 2-Thioxo-1, 2, 5, 6, 7, 8-hexahydroquinoline-3-carbonitrile (2) was easily S- alkylated to produce alkyl mercapto derivatives 3a-g. The latter compounds were cyclized to afford thienotetrahydroquinolines 4a-g. Several pyrimidothienotetrahydroquinolines 5a-d, and 6a-d were obtained from the condensation of compounds 4c-f with different reagents.
![2-[(3-cyano-5,6,7,8-tetrahydroquinolin-2-yl)sulfanyl]acetamide结构式](https://image.chemsrc.com/caspic/425/314764-01-7.png)
![3-Amino-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide结构式](https://image.chemsrc.com/caspic/233/315248-91-0.png)