Letters in Organic Chemistry

A New Practical Synthesis of Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate From (S)-3-chloro-1, 2-propanediol

C Jiang, H Hong

文献索引：Jiang, Chengjun; Hong, Huabin Letters in Organic Chemistry, 2012 , vol. 9, # 7 p. 520 - 521

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被引用次数: 3

摘要

A practical chemical synthesis of ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate ((R)-CNHB) has been accomplished from (S)-3-chloro-1, 2-propanediol, which is a main by-product originating from (S, S)-Salen Co (III) catalyzed by hydrolytic kinetic resolution (HKR) of epichlorohydrin. The new synthetic approach demonstrated an efficient utilization of organic by-product for the asymmetric synthesis of the intermediate of atorvastatin.