Journal of medicinal chemistry

Substituent constants for aliphatic functions obtained from partition coefficients

J Iwasa, T Fujita, C Hansch

文献索引：Iwasa,J. et al. J. Med. Chem., 1965 , vol. 8, p. 150 - 153

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被引用次数: 209

摘要

(3) log PCGHI (CE~)? OR-log PCsHaCHa= log PCHjOH=-1.33 log PC6HaCH OH-log PC6Hr= log PCHjOB=-1.03 Comparison of eq. 1, 2, and 3 again indicates that if the functional groups are removed by 2 or inore CH2 groups, group interaction is small and approximately constant values for log P can be additively determined. The value for ethyl methyl ketone can likewise be calculated (eq. 4). The experimentally determined value is ...