Polymer supported enantioselective reactions. II. α-Methylation of cyclohexanone

CR McArthur, PM Worster, JL Jiang…

文献索引：McArthur, Colin R.; Worster, Paul M.; Jiang, Ji-Long; Leznoff, Clifford Canadian Journal of Chemistry, 1982 , vol. 60, p. 1836 - 1841

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被引用次数: 60

摘要

Insoluble cross-linked copolymers of styrene and 1% divinylbenzene with covalently bonded (S)-2-aminoalkoxy groups were used in the enantioselective α-methylation of cyclohexanone through the corresponding imines. Enantiomeric excesses of 94% of (S)-2- methylcyclohexanone were observed on methylation at 20° C. An analogous optically active 2-aminoalkyl benzyl ether, under otherwise identical conditions, resulted in a lower ...